Your daily look at late-breaking news, upcoming events and the stories that will be talked about today:

FRANKFURT, Germany (AP) — European Central Bank head Mario Draghi says governments must ensure that pro-business reforms create economic benefits for everyone if the changes in worker protections are to find acceptance.

SEATTLE (AP) — Memo to the many places vying for Amazon's second headquarters: It ain't all food trucks and free bananas.

NEW YORK (AP) — Alyssa Milano was in bed with her two young children when a friend of a friend on Facebook suggested something that struck her as a great way to elevate the Harvey Weinstein conversation. She took the idea to Twitter, posting: "If you've been sexually harassed or assaulted write 'me too' as a reply to this tweet."

SAN DIEGO (AP) — Doctors were just guessing a decade ago when they gave Alison Cairnes' husband a new drug they hoped would shrink his lung tumors. Now she takes it too, but the choice was no guesswork. Sophisticated gene tests suggested it would fight her gastric cancer, and they were right.

A look at what's happening all around the majors today:

WASHINGTON (AP) — A bipartisan Senate deal to curb the growth of health insurance premiums is reeling after President Donald Trump reversed course and opposed the agreement and top congressional Republicans and conservatives gave it a frosty reception.

MADRID (AP) — Spain's prime minister on Wednesday urged Catalonia's leaders to back down from their bid to gain independence for the region, a day before a central government deadline that could significantly deepen the country's political crisis.

WASHINGTON (AP) — A bipartisan Senate deal to curb the growth of health insurance premiums is reeling after President Donald Trump reversed course and opposed the agreement and top congressional Republicans and conservatives gave it a frosty reception.

PLEASANTVILLE, N.J. (AP) — A New Jersey newspaper has scored an easy scoop.